SO MAGIC MUSHROOMS REALLY DO WORK:

Mushrooms induce mystical experiences
Subjects report direct experience of `beyond'
Psilocybin not `God in a pill,' scientists say
Jul. 22, 2006. 01:00 AM (Toronto Star)
NATE HERPICH
RELIGION NEWS SERVICE

A recent Johns Hopkins University School of Medicine study suggests "sacred mushrooms" can provide a religious experience that makes one see the world from a different, more positive perspective.

The study tested psilocybin, the active agent in so-called "sacred mushrooms," to determine whether it could induce "mystical experiences" in a group of 36 adults with religious backgrounds.

The answer, the study says, is an emphatic yes.

[...]

Interesting, although the article does not define "mystical experiences" very clearly.

UPDATE (28 July): Reader Roberto Labanti e-mails to note that the Psychopharmacology article is currently available for free pre-print download here. This is the abstract:

Rationale Although psilocybin has been used for centuries for religious purposes, little is known scientifically about its acute and persisting effects.
Objectives This double-blind study evaluated the acute and longer-term psychological effects of a high dose of psilocybin relative to a comparison compound administered under comfortable, supportive conditions.
Materials and methods The participants were hallucinogen-naïve adults reporting regular participation in religious or spiritual activities. Two or three sessions were conducted at 2-month intervals. Thirty volunteers received orally administered psilocybin (30 mg/70 kg) and methylphenidate hydrochloride (40 mg/70 kg) in counterbalanced order. To obscure the study design, six additional volunteers received methylphenidate in the first two sessions and unblinded psilocybin in a third session. The 8-h sessions were conducted individually. Volunteers were encouraged to close their eyes and direct their attention inward. Study monitors rated volunteers’ behavior during sessions. Volunteers completed questionnaires assessing drug effects and mystical experience immediately after and 2 months after sessions. Community observers rated changes in the volunteer’s attitudes and behavior.
Results Psilocybin produced a range of acute perceptual changes, subjective experiences, and labile moods including anxiety. Psilocybin also increased measures of mystical experience. At 2 months, the volunteers rated the psilocybin experience as having substantial personal meaning and spiritual significance and attributed to the experience sustained positive changes in attitudes and behavior consistent with changes rated by community observers.
Conclusions When administered under supportive conditions, psilocybin occasioned experiences similar to spontaneously occurring mystical experiences. The ability to occasion such experiences prospectively will allow rigorous scientific investigations of their causes and consequences.
Electronic Supplementary Material Supplementary material is available for this article at http://dx.doi.org/10.1007/s00213-006-0457-5 and is accessible for authorized users.